7-Deaza-7-fluoro modification confers on 4’-cyano-nucleosides potent activity against entecavir/adefovir-resistant HBV variants and favorable safety

We designed, synthesized and identified a novel nucleoside derivative, 4’-C-cyano-7-deaza-7-fluoro-2’-deoxyadenosine (CdFA), which exerts potent anti-HBV activity (IC(50) ~26 nM) with favorable hepatocytotoxicity (CC(50)~56 μM). Southern blot analysis using wild-type HBV (HBV(WT))-encoding-plasmid-t...

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Détails bibliographiques
Publié dans:Antiviral Res
Auteurs principaux: Hayashi, Sanae, Higashi-Kuwata, Nobuyo, Das, Debananda, Tomaya, Kota, Yamada, Kohei, Murakami, Shuko, Venzon, David J., Hattori, Shin-ichiro, Isogawa, Masanori, Sarafianos, Stefan G., Mitsuya, Hiroaki, Tanaka, Yasuhito
Format: Artigo
Langue:Inglês
Publié: 2020
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7164687/
https://ncbi.nlm.nih.gov/pubmed/32084506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.antiviral.2020.104744
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