CMCdG, a Novel Nucleoside Analog with Favorable Safety Features, Exerts Potent Activity against Wild-Type and Entecavir-Resistant Hepatitis B Virus

We designed, synthesized, and characterized a novel nucleoside analog, (1S,3S,5S)-3-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-5-hydroxy-1-(hydroxymethyl)-2-methylene-cyclopentanecarbonitrile, or 4′-cyano-methylenecarbocyclic-2′-deoxyguanosine (CMCdG), and evaluated its anti-hepatitis B virus (anti-H...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Higashi-Kuwata, Nobuyo, Hayashi, Sanae, Das, Debananda, Kohgo, Satoru, Murakami, Shuko, Hattori, Shin-ichiro, Imoto, Shuhei, Venzon, David J., Singh, Kamalendra, Sarafianos, Stefan G., Tanaka, Yasuhito, Mitsuya, Hiroaki
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2019
Témata:
Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6437475/
https://ncbi.nlm.nih.gov/pubmed/30670420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02143-18
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