A novel entecavir analogue constructing with a spiro[2.4]heptane core structure in the aglycon moiety: Its synthesis and evaluation for anti-hepatitis B virus activity

Synthesis of a novel 2′-deoxy-guanine carbocyclic nucleoside 4 constructed with spiro[2.4]heptane core structure in the aglycon moiety was carried out. Radical-mediated 5-exo-dig mode cyclization and following cyclopropanation proceeded efficiently to furnish the spiro alcohol 10. Subsequent Mitsuno...

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Publicado en:Nucleosides Nucleotides Nucleic Acids
Main Authors: Kumamoto, Hiroki, Fukano, Misato, Imoto, Shuhei, Kohgo, Satoru, Odanaka, Yuki, Amano, Masayuki, Kuwata-Higashi, Nobuyo, Mitsuya, Hiroaki, Haraguchi, Kazuhiro, Fukuhara, Kiyoshi
Formato: Artigo
Idioma:Inglês
Publicado: 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7900907/
https://ncbi.nlm.nih.gov/pubmed/28574799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15257770.2017.1322209
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