Structural features in common of HBV and HIV-1 resistance against chirally-distinct nucleoside analogues entecavir and lamivudine

par Yasutake, Yoshiaki, Hattori, Shin-ichiro, Tamura, Noriko, Matsuda, Kouki, Kohgo, Satoru, Maeda, Kenji, Mitsuya, Hiroaki
Publié dans Sci Rep (2020)

HIV-1 with HBV-associated Q151M substitution in RT becomes highly susceptible to entecavir: structural insights into HBV-RT inhibition by entecavir

par Yasutake, Yoshiaki, Hattori, Shin-ichiro, Hayashi, Hironori, Matsuda, Kouki, Tamura, Noriko, Kohgo, Satoru, Maeda, Kenji, Mitsuya, Hiroaki
Publié dans Sci Rep (2018)

Combination of a Latency-Reversing Agent With a Smac Mimetic Minimizes Secondary HIV-1 Infection in vitro

par Hattori, Shin-ichiro, Matsuda, Kouki, Tsuchiya, Kiyoto, Gatanaga, Hiroyuki, Oka, Shinichi, Yoshimura, Kazuhisa, Mitsuya, Hiroaki, Maeda, Kenji
Publié dans Front Microbiol (2018)

Regulation of the Dimerization and Activity of SARS-CoV-2 Main Protease through Reversible Glutathionylation of Cysteine 300

par Davis, David A., Bulut, Haydar, Shrestha, Prabha, Yaparla, Amulya, Jaeger, Hannah K., Hattori, Shin-ichiro, Wingfield, Paul T., Mitsuya, Hiroaki, Yarchoan, Robert
Publié dans bioRxiv (2021)

Halogen Bond Interactions of Novel HIV-1 Protease Inhibitors (PI) (GRL-001-15 and GRL-003-15) with the Flap of Protease Are Critical for Their Potent Activity against Wild-Type HIV...

par Hattori, Shin-ichiro, Hayashi, Hironori, Bulut, Haydar, Rao, Kalapala Venkateswara, Nyalapatla, Prasanth R., Hasegawa, Kazuya, Aoki, Manabu, Ghosh, Arun K., Mitsuya, Hiroaki
Publié dans Antimicrob Agents Chemother (2019)

Potent HIV-1 protease inhibitors incorporating squaramide-derived P2 ligands: Design, synthesis, and biological evaluation

par Ghosh, Arun K., Williams, Jacqueline N., Kovela, Satish, Takayama, Jun, Simpson, Hannah M., Walters, D. Eric, Hattori, Shin-ichiro, Aoki, Manabu, Mitsuya, Hiroaki
Publié dans Bioorg Med Chem Lett (2019)

Biochemical and Structural Properties of Entecavir-Resistant Hepatitis B Virus Polymerase with L180M/M204V Mutations

par Nakajima, Shogo, Watashi, Koichi, Kato, Takanobu, Muramatsu, Masamichi, Wakita, Takaji, Tamura, Noriko, Hattori, Shin-ichiro, Maeda, Kenji, Mitsuya, Hiroaki, Yasutake, Yoshiaki, Toyoda, Tetsuya
Publié dans J Virol (2021)

Influence of Advanced Age on Mycobacterium bovis BCG Vaccination in Guinea Pigs Aerogenically Infected with Mycobacterium tuberculosis

par Komine-Aizawa, Shihoko, Yamazaki, Toshio, Yamazaki, Tsuyoshi, Hattori, Shin-ichiro, Miyamoto, Yuji, Yamamoto, Naoki, Haga, Shinji, Sugitani, Masahiko, Honda, Mitsuo, Hayakawa, Satoshi, Yamamoto, Saburo
Publié 2010

GRL-079, a Novel HIV-1 Protease Inhibitor, Is Extremely Potent against Multidrug-Resistant HIV-1 Variants and Has a High Genetic Barrier against the Emergence of Resistant Variants

par Delino, Nicole S., Aoki, Manabu, Hayashi, Hironori, Hattori, Shin-ichiro, Chang, Simon B., Takamatsu, Yuki, Martyr, Cuthbert D., Das, Debananda, Ghosh, Arun K., Mitsuya, Hiroaki
Publié dans Antimicrob Agents Chemother (2018)

Design, Synthesis, and X-Ray Studies of Potent HIV-1 Protease Inhibitors incorporating aminothiochromane and aminotetrahydronaphthalene carboxamide derivatives as the P2 ligands.

par Ghosh, Arun K., Jadhav, Ravindra D., Simpson, Hannah, Kovela, Satish, Osswald, Heather, Agniswamy, Johnson, Wang, Yuan-Fang, Hattori, Shin-ichiro, Weber, Irene T., Mitsuya, Hiroaki
Publié dans Eur J Med Chem (2018)

Benzolactam-related compounds promote apoptosis of HIV-infected human cells via protein kinase C–induced HIV latency reversal

par Matsuda, Kouki, Kobayakawa, Takuya, Tsuchiya, Kiyoto, Hattori, Shin-ichiro, Nomura, Wataru, Gatanaga, Hiroyuki, Yoshimura, Kazuhisa, Oka, Shinichi, Endo, Yasuyuki, Tamamura, Hirokazu, Mitsuya, Hiroaki, Maeda, Kenji
Publié dans J Biol Chem (2019)

Design and Synthesis of Potent HIV-1 Protease Inhibitors Containing Bicyclic Oxazolidinone Scaffold as the P2 Ligands: Structure–Activity Studies and Biological and X-ray Structura...

par Ghosh, Arun K., Williams, Jacqueline N., Ho, Rachel Y., Simpson, Hannah M., Hattori, Shin-ichiro, Hayashi, Hironori, Agniswamy, Johnson, Wang, Yuan-Fang, Weber, Irene T., Mitsuya, Hiroaki
Publié dans J Med Chem (2018)

Early phase dynamics of traceable mCherry fluorescent protein-carrying HIV-1 infection in human peripheral blood mononuclear cells-transplanted NOD/SCID/Jak3(−/−) mice

par Higashi-Kuwata, Nobuyo, Ogata-Aoki, Hiromi, Hattori, Shin-ichiro, Hayashi, Hironori, Danish, Matthew, Aoki, Manabu, Shiotsu, Chiemi, Kawamura, Tatsuyoshi, Ihn, Hironobu, Kobayashi, Hisataka, Okada, Seiji, Mitsuya, Hiroaki
Publié dans Antiviral Res (2017)

CMCdG, a Novel Nucleoside Analog with Favorable Safety Features, Exerts Potent Activity against Wild-Type and Entecavir-Resistant Hepatitis B Virus

par Higashi-Kuwata, Nobuyo, Hayashi, Sanae, Das, Debananda, Kohgo, Satoru, Murakami, Shuko, Hattori, Shin-ichiro, Imoto, Shuhei, Venzon, David J., Singh, Kamalendra, Sarafianos, Stefan G., Tanaka, Yasuhito, Mitsuya, Hiroaki
Publié dans Antimicrob Agents Chemother (2019)

7-Deaza-7-fluoro modification confers on 4’-cyano-nucleosides potent activity against entecavir/adefovir-resistant HBV variants and favorable safety

par Hayashi, Sanae, Higashi-Kuwata, Nobuyo, Das, Debananda, Tomaya, Kota, Yamada, Kohei, Murakami, Shuko, Venzon, David J., Hattori, Shin-ichiro, Isogawa, Masanori, Sarafianos, Stefan G., Mitsuya, Hiroaki, Tanaka, Yasuhito
Publié dans Antiviral Res (2020)

Single atom changes in newly synthesized HIV protease inhibitors reveal structural basis for extreme affinity, high genetic barrier, and adaptation to the HIV protease plasticity

par Bulut, Haydar, Hattori, Shin-ichiro, Aoki-Ogata, Hiromi, Hayashi, Hironori, Das, Debananda, Aoki, Manabu, Davis, David A., Rao, Kalapala Venkateswara, Nyalapatla, Prasanth R., Ghosh, Arun K., Mitsuya, Hiroaki
Publié dans Sci Rep (2020)

Design, Synthesis, and X-ray Studies of Potent HIV-1 Protease Inhibitors with P2-Carboxamide Functionalities

par Ghosh, Arun K., Grillo, Alessandro, Raghavaiah, Jakka, Kovela, Satish, Johnson, Megan E., Kneller, Daniel W., Wang, Yuan-Fang, Hattori, Shin-ichiro, Higashi-Kuwata, Nobuyo, Weber, Irene T., Mitsuya, Hiroaki
Publié dans ACS Med Chem Lett (2020)

Neutralization of SARS-CoV-2 with IgG from COVID-19-convalescent plasma

par Maeda, Kenji, Higashi-Kuwata, Nobuyo, Kinoshita, Noriko, Kutsuna, Satoshi, Tsuchiya, Kiyoto, Hattori, Shin-ichiro, Matsuda, Kouki, Takamatsu, Yuki, Gatanaga, Hiroyuki, Oka, Shinichi, Sugiyama, Haruhito, Ohmagari, Norio, Mitsuya, Hiroaki
Publié dans Sci Rep (2021)

Raltegravir blocks the infectivity of red-fluorescent-protein (mCherry)-labeled HIV-1(JR-FL) in the setting of post-exposure prophylaxis in NOD/SCID/Jak3(−/−) mice transplanted wit...

par Ogata-Aoki, Hiromi, Higashi-Kuwata, Nobuyo, Hattori, Shin-ichiro, Hayashi, Hironori, Danish, Matthew, Aoki, Manabu, Shiotsu, Chiemi, Hashiguchi, Yumi, Hamada, Akinobu, Kobayashi, Hisataka, Ihn, Hironobu, Okada, Seiji, Mitsuya, Hiroaki
Publié dans Antiviral Res (2017)

Design of Highly Potent, Dual-Acting and Central-Nervous-System-Penetrating HIV-1 Protease Inhibitors with Excellent Potency against Multidrug-Resistant HIV-1 Variants

par Ghosh, Arun K., Rao, Kalapala Venkateswara, Nyalapatla, Prasanth R., Kovela, Satish, Brindisi, Margherita, Osswald, Heather L., Reddy, Bhavanam Sekhara, Agniswamy, Johnson, Wang, Yuan-Fang, Aoki, Manabu, Hattori, Shin-ichiro, Weber, Irene T., Mitsuya, Hiroaki
Publié dans ChemMedChem (2018)