GRL-079, a Novel HIV-1 Protease Inhibitor, Is Extremely Potent against Multidrug-Resistant HIV-1 Variants and Has a High Genetic Barrier against the Emergence of Resistant Variants

We identified four novel nonpeptidic human immunodeficiency virus type 1 (HIV-1) protease inhibitors (PIs), GRL-078, -079, -077, and -058, containing an alkylamine at the C-5 position of P2 tetrahydropyrano-tetrahydrofuran (Tp-THF) and a P2′ cyclopropyl (Cp) (or isopropyl)-aminobenzothiazole (Abt) m...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Delino, Nicole S., Aoki, Manabu, Hayashi, Hironori, Hattori, Shin-ichiro, Chang, Simon B., Takamatsu, Yuki, Martyr, Cuthbert D., Das, Debananda, Ghosh, Arun K., Mitsuya, Hiroaki
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2018
Témata:
Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5923169/
https://ncbi.nlm.nih.gov/pubmed/29463535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02060-17
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