GRL-0519, a Novel Oxatricyclic Ligand-Containing Nonpeptidic HIV-1 Protease Inhibitor (PI), Potently Suppresses Replication of a Wide Spectrum of Multi-PI-Resistant HIV-1 Variants In Vitro

We report that GRL-0519, a novel nonpeptidic human immunodeficiency virus type 1 (HIV-1) protease inhibitor (PI) containing tris-tetrahydrofuranylurethane (tris-THF) and a sulfonamide isostere, is highly potent against laboratory HIV-1 strains and primary clinical isolates (50% effective concentrati...

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Detalhes bibliográficos
Main Authors: Amano, Masayuki, Tojo, Yasushi, Salcedo-Gómez, Pedro Miguel, Campbell, Joseph Richard, Das, Debananda, Aoki, Manabu, Xu, Chun-Xiao, Rao, Kalapala Venkateswara, Ghosh, Arun K., Mitsuya, Hiroaki
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3632947/
https://ncbi.nlm.nih.gov/pubmed/23403426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02189-12
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