GRL-02031, a Novel Nonpeptidic Protease Inhibitor (PI) Containing a Stereochemically Defined Fused Cyclopentanyltetrahydrofuran Potent against Multi-PI-Resistant Human Immunodeficiency Virus Type 1 In Vitro

We generated a novel nonpeptidic protease inhibitor (PI), GRL-02031, by incorporating a stereochemically defined fused cyclopentanyltetrahydrofuran (Cp-THF) which exerted potent activity against a wide spectrum of human immunodeficiency virus type 1 (HIV-1) isolates, including multidrug-resistant HI...

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Detalhes bibliográficos
Main Authors: Koh, Yasuhiro, Das, Debananda, Leschenko, Sofiya, Nakata, Hirotomo, Ogata-Aoki, Hiromi, Amano, Masayuki, Nakayama, Maki, Ghosh, Arun K., Mitsuya, Hiroaki
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2650524/
https://ncbi.nlm.nih.gov/pubmed/18955518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00689-08
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