GRL-04810 and GRL-05010, Difluoride-Containing Nonpeptidic HIV-1 Protease Inhibitors (PIs) That Inhibit the Replication of Multi-PI-Resistant HIV-1 In Vitro and Possess Favorable Lipophilicity That May Allow Blood-Brain Barrier Penetration

We designed, synthesized, and identified two novel nonpeptidic human immunodeficiency virus type 1 (HIV-1) protease inhibitors (PIs), GRL-04810 and GRL-05010, containing the structure-based designed privileged cyclic ether-derived nonpeptide P2 ligand, bis-tetrahydrofuranylurethane (bis-THF), and a...

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Bibliographic Details
Main Authors: Salcedo Gómez, Pedro Miguel, Amano, Masayuki, Yashchuk, Sofiya, Mizuno, Akira, Das, Debananda, Ghosh, Arun K., Mitsuya, Hiroaki
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2013
Subjects:
Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3837900/
https://ncbi.nlm.nih.gov/pubmed/24080647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01420-13
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