A Novel Bis-Tetrahydrofuranylurethane-Containing Nonpeptidic Protease Inhibitor (PI), GRL-98065, Is Potent against Multiple-PI-Resistant Human Immunodeficiency Virus In Vitro

We designed, synthesized, and identified GRL-98065, a novel nonpeptidic human immunodeficiency virus type 1 (HIV-1) protease inhibitor (PI) containing the structure-based designed privileged cyclic ether-derived nonpeptide P2 ligand, 3(R),3a(S),6a(R)-bis-tetrahydrofuranylurethane (bis-THF), and a su...

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Detalhes bibliográficos
Main Authors: Amano, Masayuki, Koh, Yasuhiro, Das, Debananda, Li, Jianfeng, Leschenko, Sofiya, Wang, Yuan-Fang, Boross, Peter I., Weber, Irene T., Ghosh, Arun K., Mitsuya, Hiroaki
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2007
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1891396/
https://ncbi.nlm.nih.gov/pubmed/17371811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01413-06
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