A Modified P1 Moiety Enhances In Vitro Antiviral Activity against Various Multidrug-Resistant HIV-1 Variants and In Vitro Central Nervous System Penetration Properties of a Novel Nonpeptidic Protease Inhibitor, GRL-10413

We report here that GRL-10413, a novel nonpeptidic HIV-1 protease inhibitor (PI) containing a modified P1 moiety and a hydroxyethylamine sulfonamide isostere, is highly active against laboratory HIV-1 strains and primary clinical isolates (50% effective concentration [EC(50)] of 0.00035 to 0.0018 μM...

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Publicado en:Antimicrob Agents Chemother
Autores principales: Amano, Masayuki, Salcedo-Gómez, Pedro Miguel, Zhao, Rui, Yedidi, Ravikiran S., Das, Debananda, Bulut, Haydar, Delino, Nicole S., Sheri, Venkata Reddy, Ghosh, Arun K., Mitsuya, Hiroaki
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2016
Materias:
Antiviral Agents
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5118983/
https://ncbi.nlm.nih.gov/pubmed/27620483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01428-16
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