Загрузка...
A Modified P1 Moiety Enhances In Vitro Antiviral Activity against Various Multidrug-Resistant HIV-1 Variants and In Vitro Central Nervous System Penetration Properties of a Novel Nonpeptidic Protease Inhibitor, GRL-10413
We report here that GRL-10413, a novel nonpeptidic HIV-1 protease inhibitor (PI) containing a modified P1 moiety and a hydroxyethylamine sulfonamide isostere, is highly active against laboratory HIV-1 strains and primary clinical isolates (50% effective concentration [EC(50)] of 0.00035 to 0.0018 μM...
Сохранить в:
| Опубликовано в: : | Antimicrob Agents Chemother |
|---|---|
| Главные авторы: | , , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Microbiology
2016
|
| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5118983/ https://ncbi.nlm.nih.gov/pubmed/27620483 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01428-16 |
| Метки: |
Добавить метку
Нет меток, Требуется 1-ая метка записи!
|