Novel Protease Inhibitors Containing C-5-Modified bis-Tetrahydrofuranylurethane and Aminobenzothiazole as P2 and P2′ Ligands That Exert Potent Antiviral Activity against Highly Multidrug-Resistant HIV-1 with a High Genetic Barrier against the Emergence of Drug Resistance

Combination antiretroviral therapy has achieved dramatic reductions in the mortality and morbidity in people with HIV-1 infection. Darunavir (DRV) represents a most efficacious and well-tolerated protease inhibitor (PI) with a high genetic barrier to the emergence of drug-resistant HIV-1. However, h...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Takamatsu, Yuki, Aoki, Manabu, Bulut, Haydar, Das, Debananda, Amano, Masayuki, Sheri, Venkata Reddy, Kovari, Ladislau C., Hayashi, Hironori, Delino, Nicole S., Ghosh, Arun K., Mitsuya, Hiroaki
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2019
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6658756/
https://ncbi.nlm.nih.gov/pubmed/31085520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00372-19
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