P1 and P1' para-fluoro phenyl groups show enhanced binding and favorable predicted pharmacological properties: structure-based virtual screening of extended lopinavir analogs again...

od Yedidi, Ravikiran S., Liu, Zhigang, Kovari, Iulia A., Woster, Patrick M., Kovari, Ladislau C.
izdano v J Mol Graph Model (2013)

The Higher Barrier of Darunavir and Tipranavir Resistance for HIV-1 Protease

od Wang, Yong, Liu, Zhigang, Brunzelle, Joseph S., Kovari, Iulia A., Dewdney, Tamaria G., Reiter, Samuel J., Kovari, Ladislau C.
Izdano 2011

Higher Desolvation Energy Reduces Molecular Recognition in Multi-Drug Resistant HIV-1 Protease

od Wang, Yong, Dewdney, Tamaria G., Liu, Zhigang, Reiter, Samuel J., Brunzelle, Joseph S., Kovari, Iulia A., Kovari, Ladislau C.
Izdano 2012

A multi-drug resistant HIV-1 protease is resistant to the dimerization inhibitory activity of TLF-PafF

od Yedidi, Ravikiran S., Proteasa, Gheorghe, Martin, Philip D., Liu, Zhigang, Vickrey, John F., Kovari, Iulia A., Kovari, Ladislau C.
izdano v J Mol Graph Model (2014)

Genotypic, Phenotypic, and Modeling Studies of a Deletion in the β3-β4 Region of the Human Immunodeficiency Virus Type 1 Reverse Transcriptase Gene That Is Associated with Resis...

od Winters, Mark A., Coolley, Kristi L., Cheng, Peng, Girard, Yvette A., Hamdan, Hasnah, Kovari, Ladislau C., Merigan, Thomas C.
Izdano 2000

Crystal structures of multidrug-resistant HIV-1 protease in complex with two potent anti-malarial compounds

od Yedidi, Ravikiran S., Liu, Zhigang, Wang, Yong, Brunzelle, Joseph S., Kovari, Iulia A., Woster, Patrick M., Kovari, Ladislau C., Gupta, Deepak
Izdano 2012

Conserved Hydrogen Bonds and Water Molecules in MDR HIV-1 Protease Substrate Complexes

od Liu, Zhigang, Wang, Yong, Yedidi, Ravikiran S., Dewdney, Tamaria G., Reiter, Samuel J., Brunzelle, Joseph S., Kovari, Iulia A., Kovari, Ladislau C.
izdano v Biochem Biophys Res Commun (2012)

Crystallographic study of multi-drug resistant HIV-1 protease Lopinavir complex: mechanism of drug recognition and resistance

od Liu, Zhigang, Yedidi, Ravikiran S., Wang, Yong, Dewdney, Tamaria G., Reiter, Samuel J., Brunzelle, Joseph S., Kovari, Iulia A., Kovari, Ladislau C.
izdano v Biochem Biophys Res Commun (2013)

Synthesis and antiviral evaluation of novel peptidomimetics as Norovirus protease inhibitors

od Amblard, Franck, Zhou, Shaoman, Liu, Peng, Yoon, Jack, Cox, Bryan, Muzzarelli, Kendall, Kuiper, Benjamin D., Kovari, Ladislau C., Schinazi, Raymond F.
izdano v Bioorg Med Chem Lett (2018)

Contribution of the 80s loop of HIV-1 protease to the multidrug-resistance mechanism: crystallographic study of MDR769 HIV-1 protease variants

od Yedidi, Ravikiran S., Proteasa, Georghe, Martinez, Jorge L., Vickrey, John F., Martin, Philip D., Wawrzak, Zdzislaw, Liu, Zhigang, Kovari, Iulia A., Kovari, Ladislau C.
Izdano 2011

The role of mutations at codons 32, 47, 54, and 90 in HIV-1 protease flap dynamics

od Chordia, Poorvi, Dewdney, Tamaria G., Keusch, Bradley, Kuiper, Benjamin D., Ross, Kyla, Kovari, Iulia A., MacArthur, Rodger, Salimnia, Hossein, Kovari, Ladislau C.
izdano v Discoveries (Craiova) (2014)

Novel Protease Inhibitors Containing C-5-Modified bis-Tetrahydrofuranylurethane and Aminobenzothiazole as P2 and P2′ Ligands That Exert Potent Antiviral Activity against Highly Mul...

od Takamatsu, Yuki, Aoki, Manabu, Bulut, Haydar, Das, Debananda, Amano, Masayuki, Sheri, Venkata Reddy, Kovari, Ladislau C., Hayashi, Hironori, Delino, Nicole S., Ghosh, Arun K., Mitsuya, Hiroaki
izdano v Antimicrob Agents Chemother (2019)

Design, synthesis and evaluation of a potent substrate analog inhibitor identified by scanning Ala/Phe mutagenesis, mimicking substrate co-evolution, against multidrug-resistant HI...

od Yedidi, Ravikiran S., Muhuhi, Joseck M., Liu, Zhigang, Bencze, Krisztina Z., Koupparis, Kyriacos M., O'Connor, Carrie E., Kovari, Iulia A., Spaller, Mark R., Kovari, Ladislau C.
izdano v Biochem Biophys Res Commun (2013)

The L33F darunavir resistance mutation acts as a molecular anchor reducing the flexibility of the HIV-1 protease 30s and 80s loops

od Kuiper, Benjamin D., Keusch, Bradley J., Dewdney, Tamaria G., Chordia, Poorvi, Ross, Kyla, Brunzelle, Joseph S., Kovari, Iulia A., MacArthur, Rodger, Salimnia, Hossein, Kovari, Ladislau C.
izdano v Biochem Biophys Rep (2015)

Crystal Structures of a Multidrug-Resistant Human Immunodeficiency Virus Type 1 Protease Reveal an Expanded Active-Site Cavity

od Logsdon, Bradley C., Vickrey, John F., Martin, Philip, Proteasa, Gheorghe, Koepke, Jay I., Terlecky, Stanley R., Wawrzak, Zdzislaw, Winters, Mark A., Merigan, Thomas C., Kovari, Ladislau C.
Izdano 2004

Structural and Antiviral Studies of the Human Norovirus GII.4 Protease

od Muzzarelli, Kendall M., Kuiper, Benjamin, Spellmon, Nicholas, Brunzelle, Joseph, Hackett, Justin, Amblard, Franck, Zhou, Shaoman, Liu, Peng, Kovari, Iulia A., Yang, Zhe, Schinazi, Raymond F., Kovari, Ladislau C.
izdano v Biochemistry (2019)

Expression, Purification and Characterization of a GII.4 Norovirus Protease from Minerva Virus

od Kuiper, Benjamin D., Muzzarelli, Kendall M., Keusch, Bradley J., Holcomb, Joshua, Amblard, Franck, Liu, Peng, Zhou, Shaoman, Kovari, Iulia A., Yang, Zhe, Schinazi, Raymond F., Kovari, Ladislau C.
izdano v Infect Disord Drug Targets (2018)

Increased activity of unlinked Zika virus NS2B/NS3 protease compared to linked Zika virus protease

od Kuiper, Benjamin D., Slater, Kristin, Spellmon, Nicholas, Holcomb, Joshua, Medapureddy, Prasanna, Muzzarelli, Kendall M., Yang, Zhe, Ovadia, Reuben, Amblard, Franck, Kovari, Iulia A., Schinazi, Raymond F., Kovari, Ladislau C.
izdano v Biochem Biophys Res Commun (2017)