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Crystallographic study of multi-drug resistant HIV-1 protease Lopinavir complex: mechanism of drug recognition and resistance
Lopinavir (LPV) is a second generation HIV-1 protease inhibitor. Drug resistance has rapidly emerged against LPV US FDA approved it on September 15, 2000. Mutations at residues 32I, L33F, 46I, 47A, I54V, V82A, I84V and L90M render the protease drug resistant against LPV. We report the crystal struct...
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| Publicado no: | Biochem Biophys Res Commun |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4520426/ https://ncbi.nlm.nih.gov/pubmed/23792096 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2013.06.027 |
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