Higher Desolvation Energy Reduces Molecular Recognition in Multi-Drug Resistant HIV-1 Protease

Designing HIV-1 protease inhibitors that overcome drug-resistance is still a challenging task. In this study, four clinical isolates of multi-drug resistant HIV-1 proteases that exhibit resistance to all the US FDA-approved HIV-1 protease inhibitors and also reduce the substrate recognition ability...

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Main Authors: Wang, Yong, Dewdney, Tamaria G., Liu, Zhigang, Reiter, Samuel J., Brunzelle, Joseph S., Kovari, Iulia A., Kovari, Ladislau C.
Formáid: Artigo
Teanga:Inglês
Foilsithe: MDPI 2012
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4011036/
https://ncbi.nlm.nih.gov/pubmed/24832048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biology1010081
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