The Higher Barrier of Darunavir and Tipranavir Resistance for HIV-1 Protease

Darunavir and tipranavir are two inhibitors that are active against multi-drug resistant (MDR) HIV-1 protease variants. In this study, the in vitro inhibitory efficacy was tested against a MDR HIV-1 protease variant, MDR 769 82T, containing the drug resistance mutations of 46L/54V/82T/84V/90M. Cryst...

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Autores principales: Wang, Yong, Liu, Zhigang, Brunzelle, Joseph S., Kovari, Iulia A., Dewdney, Tamaria G., Reiter, Samuel J., Kovari, Ladislau C.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2011
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3188455/
https://ncbi.nlm.nih.gov/pubmed/21871444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2011.08.045
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