Synthesis and antiviral evaluation of novel peptidomimetics as Norovirus protease inhibitors

A series of tripeptidyl transition state inhibitors with new P1 and warhead moieties were synthesized and evaluated in a GI-1 norovirus replicon system and against GII-4 and GI-1 norovirus proteases. Compound 19, containing a 6-membered ring at the P1 position and a reactive aldehyde warhead exhibit...

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Bibliographic Details
Published in:Bioorg Med Chem Lett
Main Authors: Amblard, Franck, Zhou, Shaoman, Liu, Peng, Yoon, Jack, Cox, Bryan, Muzzarelli, Kendall, Kuiper, Benjamin D., Kovari, Ladislau C., Schinazi, Raymond F.
Format: Artigo
Language:Inglês
Published: 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6425952/
https://ncbi.nlm.nih.gov/pubmed/29779977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2018.05.012
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