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Crystal structures of multidrug-resistant HIV-1 protease in complex with two potent anti-malarial compounds
Two potent inhibitors (compounds 1 and 2) of malarial aspartyl protease, plasmepsin-II, were evaluated against wild type (NL4-3) and multidrug-resistant clinical isolate 769 (MDR) variants of human immunodeficiency virus type-1 (HIV-1) aspartyl protease. Enzyme inhibition assays showed that both 1 a...
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| Autori principali: | , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3351498/ https://ncbi.nlm.nih.gov/pubmed/22469467 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2012.03.096 |
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