Biochemical and Structural Properties of Entecavir-Resistant Hepatitis B Virus Polymerase with L180M/M204V Mutations

Entecavir (ETV) is a widely used anti-hepatitis B virus (HBV) drug. However, the emergence of resistant mutations in HBV reverse transcriptase (RT) results in treatment failure. To understand the mechanism underlying the development of ETV resistance by HBV RT, we analyzed the L180M, M204V, and L180...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Nakajima, Shogo, Watashi, Koichi, Kato, Takanobu, Muramatsu, Masamichi, Wakita, Takaji, Tamura, Noriko, Hattori, Shin-ichiro, Maeda, Kenji, Mitsuya, Hiroaki, Yasutake, Yoshiaki, Toyoda, Tetsuya
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2021
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8312879/
https://ncbi.nlm.nih.gov/pubmed/34076480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02401-20
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