Biochemical and Structural Properties of Entecavir-Resistant Hepatitis B Virus Polymerase with L180M/M204V Mutations

Entecavir (ETV) is a widely used anti-hepatitis B virus (HBV) drug. However, the emergence of resistant mutations in HBV reverse transcriptase (RT) results in treatment failure. To understand the mechanism underlying the development of ETV resistance by HBV RT, we analyzed the L180M, M204V, and L180...

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Bibliographische Detailangaben
Veröffentlicht in:J Virol
Hauptverfasser: Nakajima, Shogo, Watashi, Koichi, Kato, Takanobu, Muramatsu, Masamichi, Wakita, Takaji, Tamura, Noriko, Hattori, Shin-ichiro, Maeda, Kenji, Mitsuya, Hiroaki, Yasutake, Yoshiaki, Toyoda, Tetsuya
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2021
Schlagworte:
Vaccines and Antiviral Agents
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8312879/
https://ncbi.nlm.nih.gov/pubmed/34076480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02401-20
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