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Design, Synthesis, and X-ray Studies of Potent HIV-1 Protease Inhibitors with P2-Carboxamide Functionalities

[Image: see text] The design, synthesis, biological evaluation, and X-ray structural studies are reported for a series of highly potent HIV-1 protease inhibitors. The inhibitors incorporated stereochemically defined amide-based bicyclic and tricyclic ether derivatives as the P2 ligands with (R)-hydr...

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Bibliografiske detaljer
Udgivet i:ACS Med Chem Lett
Main Authors: Ghosh, Arun K., Grillo, Alessandro, Raghavaiah, Jakka, Kovela, Satish, Johnson, Megan E., Kneller, Daniel W., Wang, Yuan-Fang, Hattori, Shin-ichiro, Higashi-Kuwata, Nobuyo, Weber, Irene T., Mitsuya, Hiroaki
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2020
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7549267/
https://ncbi.nlm.nih.gov/pubmed/33062180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00670
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