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Potent HIV-1 protease inhibitors incorporating squaramide-derived P2 ligands: Design, synthesis, and biological evaluation

We describe the design, synthesis, and biological evaluation of novel HIV-1 protease inhibitors containing a squaramide-derived scaffold as the P2 ligand in combination with a (R)-hydroxyethylamine ine sulfonamide isostere. Inhibitor 3h with an N-methyl-3-(R)-aminotetrahydrofuranyl squaramide P2-lig...

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Bibliografiske detaljer
Udgivet i:Bioorg Med Chem Lett
Main Authors: Ghosh, Arun K., Williams, Jacqueline N., Kovela, Satish, Takayama, Jun, Simpson, Hannah M., Walters, D. Eric, Hattori, Shin-ichiro, Aoki, Manabu, Mitsuya, Hiroaki
Format: Artigo
Sprog:Inglês
Udgivet: 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6711809/
https://ncbi.nlm.nih.gov/pubmed/31416666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2019.08.006
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