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Structure-Based Design of Highly Potent HIV-1 Protease Inhibitors Containing New Tricyclic Ring P2-Ligands: Design, Synthesis, Biological, and X-ray Structural Studies

We describe here design, synthesis, and biological evaluation of a series of highly potent HIV-1 protease inhibitors containing stereochemically defined and unprecedented tricyclic furanofuran derivatives as P2 ligands in combination with a variety of sulfonamide derivatives as P2’ ligands. These in...

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Detaylı Bibliyografya
Yayımlandı:J Med Chem
Asıl Yazarlar: Ghosh, Arun K., Kovela, Satish, Osswald, Heather L., Amano, Masayuki, Aoki, Manabu, Agniswamy, Johnson, Wang, Yuan-Fang, Weber, Irene T., Mitsuya, Hiroaki
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2020
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7425579/
https://ncbi.nlm.nih.gov/pubmed/32348139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.0c00202
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