Design and Synthesis of Highly Potent HIV-1 Protease Inhibitors Containing Tricyclic Fused Ring Systems as Novel P2-ligands: Structure-Activity Studies, Biological and X-ray Structural Analysis

The design, synthesis, and biological evaluation of a new class of HIV-1 protease inhibitors containing stereochemically defined fused tricyclic polyethers as the P2 ligands and a variety of sulfonamide derivatives as the P2′ ligands, are described. A number of ring sizes and various substituent eff...

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Vydáno v:J Med Chem
Hlavní autoři: Ghosh, Arun K., Nyalapatla, Prasanth R., Kovela, Satish, Rao, Kalapala Venkateswara, Brindisi, Margherita, Osswald, Heather L., Amano, Masayuki, Aoki, Manabu, Agniswamy, Johnson, Wang, Yuan-Fang, Weber, Irene T., Mitsuya, Hiroaki
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6044451/
https://ncbi.nlm.nih.gov/pubmed/29763303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.8b00298
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