Potent HIV-1 Protease Inhibitors Containing Carboxylic and Boronic Acids: Effect on Enzyme Inhibition and Antiviral Activity and Protein-ligand X-ray Structural Studies

We report here the synthesis and biological evaluation of phenylcarboxylic acid and phenylboronic acid containing HIV-1 protease inhibitors and their functional effect on enzyme inhibition and antiviral activity in MT-2 cell lines. Inhibitors bearing bis-THF ligand as P2 ligand and phenylcarboxylic...

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Publicado no:ChemMedChem
Main Authors: Ghosh, Arun K., Xia, Zilei, Kovela, Satish, Robinson, William L., Johnson, Megan E., Kneller, Daniel W., Wang, Yuan-Fang, Aoki, Manabu, Takamatsu, Yuki, Weber, Irene T., Mitsuya, Hiroaki
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6842059/
https://ncbi.nlm.nih.gov/pubmed/31549492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201900508
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