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Asymmetric Diels–Alder reaction of 3-(acyloxy)acryloyl oxazolidinones: optically active synthesis of a high-affinity ligand for potent HIV-1 protease inhibitors

We describe here our investigation of the asymmetric Diels–Alder reaction of chiral 3-(acyloxy)acryloyl oxazolidinones as dienophiles in various Lewis-acid promoted reactions with cyclopentadiene. The resulting highly functionalized cycloadducts are useful intermediates for the synthesis, particular...

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Bibliografiske detaljer
Udgivet i:RSC Adv
Main Authors: Ghosh, Arun K., Grillo, Alessandro, Kovela, Satish, Brindisi, Margherita
Format: Artigo
Sprog:Inglês
Udgivet: The Royal Society of Chemistry 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7351138/
https://ncbi.nlm.nih.gov/pubmed/32655859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9ra10178k
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