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Nature Inspired Molecular Design: Stereoselective Synthesis of Bicyclic and Polycyclic Ethers for Potent HIV-1 Protease Inhibitors

We have developed a conceptually new generation of non-peptidic HIV-1 protease inhibitors incorporating novel structural templates inspired by nature. This has resulted in protease inhibitors with exceptional potency and excellent pharmacological and drug-resistance profiles. The design of a stereoc...

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Bibliografski detalji
Izdano u:Asian J Org Chem
Glavni autori: Ghosh, Arun K., Brindisi, Margherita
Format: Artigo
Jezik:Inglês
Izdano: 2018
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6781882/
https://ncbi.nlm.nih.gov/pubmed/31595212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ajoc.201800255
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