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An Efficient Synthesis of Hydroxyethylene Dipeptide Isosteres: The Core Unit of Potent HIV-1 Protease Inhibitors

An efficient and stereocontrolled synthesis of hydroxyethylene dipeptide isosteres 1 from commercially available, optically pure D-mannose is described. This synthesis represents a practical and enantioselective entry to a range of other dipeptide isosteres, which are not limited to amino acid deriv...

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Bibliografski detalji
Izdano u:J Org Chem
Glavni autori: Ghosh, Arun K., McKee, Sean P., Thompson, Wayne J.
Format: Artigo
Jezik:Inglês
Izdano: 1991
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6214462/
https://ncbi.nlm.nih.gov/pubmed/30393394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo00023a009
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