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RING-CLOSING METATHESIS STRATEGY TO UNSATURATED γ- AND δ-LACTONES: SYNTHESIS OF HYDROXYETHYLENE ISOSTERE FOR PROTEASE INHIBITORS
Ring-closing olefin metathesis of acrylates derived from allylic and homo allylic alcohols in the presence of the Grubbs’ catalyst (10–15 mol%) and titanium isopropoxide (0.3–3 equiv) provided ready access to α, β-unsaturated γ- and δ-lactones and an important dipeptide isostere intermediate....
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| Publicado no: | Tetrahedron Lett |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
1998
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6223311/ https://ncbi.nlm.nih.gov/pubmed/30422130 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S0040-4039(98)00887-9 |
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