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Potent HIV-1 Protease Inhibitors: Stereoselective Synthesis of a Dipeptide Mimic
The synthesis of a differentially protected dipeptide mimic 10 in enantiomerically pure form is described. The key step involves the epimerization of the C-2 center of the lactone 4, hydrolysis and protection of the resulting hydroxy acid, followed by Curtius rearrangement to introduce the urethane...
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| Publicado no: | J Org Chem |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
1993
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6177225/ https://ncbi.nlm.nih.gov/pubmed/30310240 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo00057a011 |
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