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Potent HIV-1 Protease Inhibitors: Stereoselective Synthesis of a Dipeptide Mimic

The synthesis of a differentially protected dipeptide mimic 10 in enantiomerically pure form is described. The key step involves the epimerization of the C-2 center of the lactone 4, hydrolysis and protection of the resulting hydroxy acid, followed by Curtius rearrangement to introduce the urethane...

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Bibliografische gegevens
Gepubliceerd in:J Org Chem
Hoofdauteurs: Ghosh, Arun K., McKee, Sean P., Thompson, Wayne J., Darke, Paul L., Zugay, Joan C.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 1993
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6177225/
https://ncbi.nlm.nih.gov/pubmed/30310240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo00057a011
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