4′-Modified Nucleoside Analogs: Potent Inhibitors Active against Entecavir-resistant Hepatitis B Virus

Certain nucleoside/nucleotide reverse transcriptase (RT) inhibitors (NRTIs) are effective against HIV-1 and HBV. However, both viruses often acquire NRTI resistance, making it crucial to develop more potent agents that offer profound viral suppression. We report here that 4′-C-cyano-2-amino-2′-deoxy...

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Veröffentlicht in:Hepatology
Hauptverfasser: Takamatsu, Yuki, Tanaka, Yasuhito, Kohgo, Satoru, Murakami, Shuko, Singh, Kamalendra, Das, Debananda, Venzon, David J., Amano, Masayuki, Higashi-Kuwata, Nobuyo, Aoki, Manabu, Delino, Nicole S., Hayashi, Sanae, Takahashi, Satoru, Sukenaga, Yoshikazu, Haraguchi, Kazuhiro, Sarafianos, Stefan G., Maeda, Kenji, Mitsuya, Hiroaki
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4589464/
https://ncbi.nlm.nih.gov/pubmed/26122273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.27962
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