Dimerization of HIV-1 protease occurs through two steps relating to the mechanism of protease dimerization inhibition by darunavir

Dimerization of HIV-1 protease (PR) subunits is an essential process for PR’s acquisition of proteolytic activity, which plays a critical role in the maturation of HIV-1. Recombinant wild-type PR (PR(WT)) proved to dimerize, as examined with electrospray ionization mass spectrometry; however, two ac...

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Detalhes bibliográficos
Main Authors: Hayashi, Hironori, Takamune, Nobutoki, Nirasawa, Takashi, Aoki, Manabu, Morishita, Yoshihiko, Das, Debananda, Koh, Yasuhiro, Ghosh, Arun K., Misumi, Shogo, Mitsuya, Hiroaki
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4142999/
https://ncbi.nlm.nih.gov/pubmed/25092296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1400027111
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