Loss of Protease Dimerization Inhibition Activity of Darunavir Is Associated with the Acquisition of Resistance to Darunavir by HIV-1

Dimerization of HIV protease is essential for the acquisition of protease's proteolytic activity. We previously identified a group of HIV protease dimerization inhibitors, including darunavir (DRV). In the present work, we examine whether loss of DRV's protease dimerization inhibition acti...

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Detalhes bibliográficos
Main Authors: Koh, Yasuhiro, Aoki, Manabu, Danish, Matthew L., Aoki-Ogata, Hiromi, Amano, Masayuki, Das, Debananda, Shafer, Robert W., Ghosh, Arun K., Mitsuya, Hiroaki
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2011
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3196396/
https://ncbi.nlm.nih.gov/pubmed/21813613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.05121-11
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