In Vitro Selection of Highly Darunavir-Resistant and Replication-Competent HIV-1 Variants by Using a Mixture of Clinical HIV-1 Isolates Resistant to Multiple Conventional Protease Inhibitors

We attempted to select HIV-1 variants resistant to darunavir (DRV), which potently inhibits the enzymatic activity and dimerization of protease and has a high genetic barrier to HIV-1 development of resistance to DRV. We conducted selection using a mixture of 8 highly multi-protease inhibitor (PI)-r...

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Detalhes bibliográficos
Main Authors: Koh, Yasuhiro, Amano, Masayuki, Towata, Tomomi, Danish, Matthew, Leshchenko-Yashchuk, Sofiya, Das, Debananda, Nakayama, Maki, Tojo, Yasushi, Ghosh, Arun K., Mitsuya, Hiroaki
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2977898/
https://ncbi.nlm.nih.gov/pubmed/20810732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00967-10
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