Influence of Charge and Steric Bulk in C-24 Region on the Interaction of Bile Acids with Human Apical Sodium Dependent Bile Acid Transporter (hASBT)

Por Balakrishnan, Anand, Wring, Stephen A., Coop, Andrew, Polli, James E.
Publicado em 2006

Method to Screen Substrates of Apical Sodium-Dependent Bile Acid Transporter

Por Rais, Rana, Gonzalez, Pablo M., Zheng, Xiaowan, Wring, Stephen A., Polli, James E.
Publicado em 2008

SCY-078 Is Fungicidal against Candida Species in Time-Kill Studies

Por Scorneaux, Bernard, Angulo, David, Borroto-Esoda, Katyna, Ghannoum, Mahmoud, Peel, Michael, Wring, Stephen
Publicado no Antimicrob Agents Chemother (2017)

SCY-635, a Novel Nonimmunosuppressive Analog of Cyclosporine That Exhibits Potent Inhibition of Hepatitis C Virus RNA Replication In Vitro

Por Hopkins, Sam, Scorneaux, Bernard, Huang, Zhuhui, Murray, Michael G., Wring, Stephen, Smitley, Craig, Harris, Richard, Erdmann, Frank, Fischer, Gunter, Ribeill, Yves
Publicado em 2010

Enfuvirtide Cerebrospinal Fluid (CSF) Pharmacokinetics and Potential Use in Defining CSF HIV-1 Origin

Por Price, Richard W, Parham, Robin, Lu, Jing, Wring, Stephen A., Baker, Brian, Sailstad, Jeff, Hoh, Rebecca, Liegler, Teri, Spudich, Serena, Kuritzkes, Daniel R, Deeks, Steven G
Publicado em 2008

Synthesis and evaluation of analogs of 5'-(((Z)-4-amino-2-butenyl)methylamino)-5'-deoxyadenosine (MDL 73811, or AbeAdo) – an inhibitor of S-adenosylmethionine decarboxylase with an...

Por Brockway, Anthony J., Volkov, Oleg A., Cosner, Casey C., MacMillan, Karen S., Wring, Stephen A., Richardson, Thomas E., Peel, Michael, Phillips, Margaret A., De Brabander, Jef K.
Publicado no Bioorg Med Chem (2017)

Pharmacokinetics and pharmacodynamics utilizing unbound target tissue exposure as part of a disposition-based rationale for lead optimization of benzoxaboroles in the treatment of...

Por WRING, STEPHEN, GAUKEL, ERIC, NARE, BAKELA, JACOBS, ROBERT, BEAUDET, BETH, BOWLING, TANA, MERCER, LUKE, BACCHI, CYRUS, YARLETT, NIGEL, RANDOLPH, RYAN, PARHAM, ROBIN, REWERTS, CINDY, PLATNER, JACOB, DON, ROBERT
Publicado em 2014

Preclinical Pharmacokinetics and Pharmacodynamic Target of SCY-078, a First-in-Class Orally Active Antifungal Glucan Synthesis Inhibitor, in Murine Models of Disseminated Candidias...

Por Wring, Stephen A., Randolph, Ryan, Park, SeongHee, Abruzzo, George, Chen, Qing, Flattery, Amy, Garrett, Graig, Peel, Michael, Outcalt, Russell, Powell, Kendall, Trucksis, Michelle, Angulo, David, Borroto-Esoda, Katyna
Publicado no Antimicrob Agents Chemother (2017)

Design of helical, oligomeric HIV-1 fusion inhibitor peptides with potent activity against enfuvirtide-resistant virus

Por Dwyer, John J., Wilson, Karen L., Davison, Donna K., Freel, Stephanie A., Seedorff, Jennifer E., Wring, Stephen A., Tvermoes, Nicolai A., Matthews, Thomas J., Greenberg, Michael L., Delmedico, Mary K.
Publicado em 2007

Identification of Trypanosoma brucei AdoMetDC inhibitors using a high-throughput mass spectrometry-based assay

Por Volkov, Oleg A., Cosner, Casey C., Brockway, Anthony J., Kramer, Martin, Booker, Michael, Zhong, Shihua, Ketcherside, Ariel, Wei, Shuguang, Longgood, Jamie, McCoy, Melissa, Richardson, Thomas E., Wring, Stephen A., Peel, Michael, Klinger, Jeffrey D., Posner, Bruce A., De Brabander, Jef K., Phillips, Margaret A.
Publicado no ACS Infect Dis (2017)

Discovery of Novel Orally Bioavailable Oxaborole 6-Carboxamides That Demonstrate Cure in a Murine Model of Late-Stage Central Nervous System African Trypanosomiasis

Por Nare, Bakela, Wring, Stephen, Bacchi, Cyrus, Beaudet, Beth, Bowling, Tana, Brun, Reto, Chen, Daitao, Ding, Charles, Freund, Yvonne, Gaukel, Eric, Hussain, Ali, Jarnagin, Kurt, Jenks, Matthew, Kaiser, Marcel, Mercer, Luke, Mejia, Elena, Noe, Andy, Orr, Matt, Parham, Robin, Plattner, Jacob, Randolph, Ryan, Rattendi, Donna, Rewerts, Cindy, Sligar, Jessica, Yarlett, Nigel, Don, Robert, Jacobs, Robert
Publicado em 2010

SCYX-7158, an Orally-Active Benzoxaborole for the Treatment of Stage 2 Human African Trypanosomiasis

Por Jacobs, Robert T., Nare, Bakela, Wring, Stephen A., Orr, Matthew D., Chen, Daitao, Sligar, Jessica M., Jenks, Matthew X., Noe, Robert A., Bowling, Tana S., Mercer, Luke T., Rewerts, Cindy, Gaukel, Eric, Owens, Jennifer, Parham, Robin, Randolph, Ryan, Beaudet, Beth, Bacchi, Cyrus J., Yarlett, Nigel, Plattner, Jacob J., Freund, Yvonne, Ding, Charles, Akama, Tsutomu, Zhang, Y.-K., Brun, Reto, Kaiser, Marcel, Scandale, Ivan, Don, Robert
Publicado em 2011