SCY-078 Demonstrates Significant Tissue Penetration in Rats and Mice Following Oral or IV Administration

Autor Barat, Stephen, Borroto-Esoda, Katyna, Angulo, David
Vydáno v Open Forum Infect Dis (2017)

In Vitro Activity of a Novel Glucan Synthase Inhibitor, SCY-078, against Clinical Isolates of Candida auris

Autor Berkow, Elizabeth L., Angulo, David, Lockhart, Shawn R.
Vydáno v Antimicrob Agents Chemother (2017)

733. Ibrexafungerp Demonstrates Potent and Consistent In Vitro Activity Against >400 Global Candida auris Isolates, Including isolates with Elevated MIC’s to Echinocandins

Autor Borroto-Esoda, Katyna, Angulo, David A, Azie, Nkechi
Vydáno v Open Forum Infect Dis (2020)

Assessment of the In Vitro Antifungal Activity of SCY-078 Against a Collection of C. parapsilosis Clinical Isolates

Autor Barat, Stephen, Angulo, David, Borroto-Esoda, Katyna, Ghannoum, Mahmoud
Vydáno v Open Forum Infect Dis (2017)

SCY-078, a Novel Fungicidal Agent, Demonstrates Distribution to Tissues Associated with Fungal Infections during Mass Balance Studies with Intravenous and Oral [(14)C]SCY-078 in Al...

Autor Wring, Stephen, Borroto-Esoda, Katyna, Solon, Eric, Angulo, David
Vydáno v Antimicrob Agents Chemother (2019)

In Vitro pH Activity of Ibrexafungerp against Fluconazole-Susceptible and -Resistant Candida Isolates from Women with Vulvovaginal Candidiasis

Autor Sobel, Jack D., Borroto-Esoda, Katyna, Azie, Nkechi, Angulo, David
Vydáno v Antimicrob Agents Chemother (2021)

SCY-078 Demonstrates Significant Antifungal Activity in a Murine Model of Invasive Aspergillosis

Autor Borroto-Esoda, Katyna, Barat, Stephen, Angulo, David, Holden, Kirsty, Warn, Peter
Vydáno v Open Forum Infect Dis (2017)

Phosphoprotein profiling by PA-GeLC-MS/MS

Autor Kristjansdottir, Kolbrun, Wolfgeher, Donald, Lucius, Nick, Angulo, David Sigfredo, Kron, Stephen J.
Vydáno 2008

672. Activity of Ibrexafungerp (Formerly SCY-078) Against Candida auris: In vitro, In Vivo, and Clinical Case Studies of Candidemia

Autor Barat, Stephen, Borroto-Esoda, Katyna, Ghannoum, Mahmoud, Berkow, Elizabeth, Angulo, David A
Vydáno v Open Forum Infect Dis (2019)

1251. Prevention of Pneumocystis Pneumonia by Ibrexafungerp in a Murine Prophylaxis Model

Autor Borroto-Esoda, Katyna, Azie, Nkechi, Ashbaugh, Alan, Cushion, Melanie, Angulo, David A
Vydáno v Open Forum Infect Dis (2020)

SCY-078 Is Fungicidal against Candida Species in Time-Kill Studies

Autor Scorneaux, Bernard, Angulo, David, Borroto-Esoda, Katyna, Ghannoum, Mahmoud, Peel, Michael, Wring, Stephen
Vydáno v Antimicrob Agents Chemother (2017)

De Novo Acquisition of Resistance to SCY-078 in Candida glabrata Involves FKS Mutations That both Overlap and Are Distinct from Those Conferring Echinocandin Resistance

Autor Jiménez-Ortigosa, Cristina, Perez, Winder B., Angulo, David, Borroto-Esoda, Katyna, Perlin, David S.
Vydáno v Antimicrob Agents Chemother (2017)

In Vitro Activity of Ibrexafungerp, a Novel Glucan Synthase Inhibitor against Candida glabrata Isolates with FKS Mutations

Autor Nunnally, Natalie S., Etienne, Kizee A., Angulo, David, Lockhart, Shawn R., Berkow, Elizabeth L.
Vydáno v Antimicrob Agents Chemother (2019)

Lack of Impact by SCY‐078, a First‐in‐Class Oral Fungicidal Glucan Synthase Inhibitor, on the Pharmacokinetics of Rosiglitazone, a Substrate for CYP450 2C8, Supports the Low Risk f...

Autor Wring, Stephen, Murphy, Gail, Atiee, George, Corr, Christy, Hyman, Michele, Willett, Michael, Angulo, David
Vydáno v J Clin Pharmacol (2018)

Ibrexafungerp, a Novel Oral Triterpenoid Antifungal in Development: Overview of Antifungal Activity Against Candida glabrata

Autor Gamal, Ahmed, Chu, Sherman, McCormick, Thomas S., Borroto-Esoda, Katyna, Angulo, David, Ghannoum, Mahmoud A.
Vydáno v Front Cell Infect Microbiol (2021)

Synchronous vs. Asynchronous Chain Motion in α-Synuclein Contact Dynamics

Autor Urie, Kristopher G., Angulo, David, Lee, Jennifer C., Kozak, John J., Gray, Harry B., Winkler, Jay R.
Vydáno 2009

Penetration of Ibrexafungerp (Formerly SCY-078) at the Site of Infection in an Intra-abdominal Candidiasis Mouse Model

Autor Lee, Annie, Prideaux, Brendan, Zimmerman, Matthew, Carter, Claire, Barat, Stephen, Angulo, David, Dartois, Véronique, Perlin, David S., Zhao, Yanan
Vydáno v Antimicrob Agents Chemother (2020)

Investigating quantitation of phosphorylation using MALDI-TOF mass spectrometry

Autor Parker, Laurie, Engel-Hall, Aaron, Drew, Kevin, Steinhardt, George, Helseth, Donald L., Jabon, David, McMurry, Timothy, Angulo, David S., Kron, Stephen J.
Vydáno 2008

Case report of Tourniquet ALPPS and simultaneous sleeve gastrectomy: A valuable association to achieve an adequate future liver remnant in obese patients

Autor Brusadin, Roberto, López-López, Víctor, de Angulo, David Ruiz, López-Conesa, Asunción, Navarro-Barrios, Álvaro, Caballero-Planes, Albert, Parrilla-Paricio, Pascual, Robles-Campos, Ricardo
Vydáno v Medicine (Baltimore) (2020)

Combination Therapy with Ibrexafungerp (Formerly SCY-078), a First-in-Class Triterpenoid Inhibitor of (1→3)-β-d-Glucan Synthesis, and Isavuconazole for Treatment of Experimental In...

Autor Petraitis, Vidmantas, Petraitiene, Ruta, Katragkou, Aspasia, Maung, Bo Bo Win, Naing, Ethan, Kavaliauskas, Povilas, Barat, Stephen, Borroto-Esoda, Katyna, Azie, Nkechi, Angulo, David, Walsh, Thomas J.
Vydáno v Antimicrob Agents Chemother (2020)