Enfumafungin Derivative MK-3118 Shows Increased In Vitro Potency against Clinical Echinocandin-Resistant Candida Species and Aspergillus Species Isolates

by Jiménez-Ortigosa, Cristina, Paderu, Padmaja, Motyl, Mary R., Perlin, David S.
Published 2014

Genetic Drivers of Multidrug Resistance in Candida glabrata

by Healey, Kelley R., Jimenez Ortigosa, Cristina, Shor, Erika, Perlin, David S.
Published in Front Microbiol (2016)

Emergence of Echinocandin Resistance Due to a Point Mutation in the fks1 Gene of Aspergillus fumigatus in a Patient with Chronic Pulmonary Aspergillosis

by Jiménez-Ortigosa, Cristina, Moore, Caroline, Denning, David W., Perlin, David S.
Published in Antimicrob Agents Chemother (2017)

De Novo Acquisition of Resistance to SCY-078 in Candida glabrata Involves FKS Mutations That both Overlap and Are Distinct from Those Conferring Echinocandin Resistance

by Jiménez-Ortigosa, Cristina, Perez, Winder B., Angulo, David, Borroto-Esoda, Katyna, Perlin, David S.
Published in Antimicrob Agents Chemother (2017)

Rapid Detection of ERG11-Associated Azole Resistance and FKS-Associated Echinocandin Resistance in Candida auris

by Hou, Xin, Lee, Annie, Jiménez-Ortigosa, Cristina, Kordalewska, Milena, Perlin, David S., Zhao, Yanan
Published in Antimicrob Agents Chemother (2018)

Quick Detection of FKS1 Mutations Responsible for Clinical Echinocandin Resistance in Candida albicans

by Dudiuk, Catiana, Gamarra, Soledad, Jimenez-Ortigosa, Cristina, Leonardelli, Florencia, Macedo, Daiana, Perlin, David S., Garcia-Effron, Guillermo
Published in J Clin Microbiol (2015)

Limited ERG11 Mutations Identified in Isolates of Candida auris Directly Contribute to Reduced Azole Susceptibility

by Healey, Kelley R., Kordalewska, Milena, Jiménez Ortigosa, Cristina, Singh, Ashutosh, Berrío, Indira, Chowdhary, Anuradha, Perlin, David S.
Published in Antimicrob Agents Chemother (2018)

Target Enzyme Mutations Confer Differential Echinocandin Susceptibilities in Candida kefyr

by Staab, Janet F., Neofytos, Dionysios, Rhee, Peter, Jiménez-Ortigosa, Cristina, Zhang, Sean X., Perlin, David S., Marr, Kieren A.
Published 2014

Differential Regulation of Echinocandin Targets Fks1 and Fks2 in Candida glabrata by the Post-Transcriptional Regulator Ssd1

by Healey, Kelley R., Paderu, Padmaja, Hou, Xin, Jimenez Ortigosa, Cristina, Bagley, Nicole, Patel, Biren, Zhao, Yanan, Perlin, David S.
Published in J Fungi (Basel) (2020)

Set of Classical PCRs for Detection of Mutations in Candida glabrata FKS Genes Linked with Echinocandin Resistance

by Dudiuk, Catiana, Gamarra, Soledad, Leonardeli, Florencia, Jimenez-Ortigosa, Cristina, Vitale, Roxana G., Afeltra, Javier, Perlin, David S., Garcia-Effron, Guillermo
Published 2014

CD101: a novel long‐acting echinocandin

by Zhao, Yanan, Perez, Winder B., Jiménez‐Ortigosa, Cristina, Hough, Grayson, Locke, Jeffrey B., Ong, Voon, Bartizal, Ken, Perlin, David S.
Published in Cell Microbiol (2016)

Tolerance to Caspofungin in Candida albicans Is Associated with at Least Three Distinctive Mechanisms That Govern Expression of FKS Genes and Cell Wall Remodeling

by Yang, Feng, Zhang, Lulu, Wakabayashi, Hironao, Myers, Jason, Jiang, Yuanying, Cao, Yongbing, Jimenez-Ortigosa, Cristina, Perlin, David S., Rustchenko, Elena
Published in Antimicrob Agents Chemother (2017)

Correction for Yang et al., “Tolerance to Caspofungin in Candida albicans Is Associated with at Least Three Distinctive Mechanisms That Govern Expression of FKS Genes and Cell Wall...

by Yang, Feng, Zhang, Lulu, Wakabayashi, Hironao, Myers, Jason, Jiang, Yuanying, Cao, Yongbing, Jimenez-Ortigosa, Cristina, Perlin, David S., Rustchenko, Elena
Published in Antimicrob Agents Chemother (2018)

Breakthrough Candidemia Due to Multidrug-Resistant Candida glabrata during Prophylaxis with a Low Dose of Micafungin

by Bizerra, Fernando César, Jimenez-Ortigosa, Cristina, Souza, Ana Carolina R., Breda, Giovanni Luis, Queiroz-Telles, Flávio, Perlin, David S., Colombo, Arnaldo L.
Published 2014

Significantly Improved Pharmacokinetics Enhances In Vivo Efficacy of APX001 against Echinocandin- and Multidrug-Resistant Candida Isolates in a Mouse Model of Invasive Candidiasis

by Zhao, Yanan, Lee, Min Hee, Paderu, Padmaja, Lee, Annie, Jimenez-Ortigosa, Cristina, Park, Steven, Mansbach, Robert S., Shaw, Karen Joy, Perlin, David S.
Published in Antimicrob Agents Chemother (2018)

Cryo-Electron Tomography of Candida glabrata Plasma Membrane Proteins

by Jiménez-Ortigosa, Cristina, Jiang, Jennifer, Chen, Muyuan, Kuang, Xuyuan, Healey, Kelley R., Castellano, Paul, Boparai, Nikpreet, Ludtke, Steven J., Perlin, David S., Dai, Wei
Published in J Fungi (Basel) (2021)

Echinocandin-resistant Candida tropicalis Bloodstream Infections

by Sfeir, Maroun, Jiménez-Ortigosa, Cristina, Schuetz, Audrey, Jenkins, Stephen, Jones, Sian, Soave, Rosemary, Van Besien, Koen, Satlin, Michael, Small, Catherine, Perlin, David, Walsh, Thomas
Published in Open Forum Infect Dis (2017)

Breakthrough Bloodstream Infections Caused by Echinocandin-Resistant Candida tropicalis: An Emerging Threat to Immunocompromised Patients with Hematological Malignancies

by Sfeir, Maroun M., Jiménez-Ortigosa, Cristina, Gamaletsou, Maria N., Schuetz, Audrey N., Soave, Rosemary, Van Besien, Koen, Small, Catherine B., Perlin, David S., Walsh, Thomas J.
Published in J Fungi (Basel) (2020)

Increasing Echinocandin Resistance in Candida glabrata: Clinical Failure Correlates With Presence of FKS Mutations and Elevated Minimum Inhibitory Concentrations

by Alexander, Barbara D., Johnson, Melissa D., Pfeiffer, Christopher D., Jiménez-Ortigosa, Cristina, Catania, Jelena, Booker, Rachel, Castanheira, Mariana, Messer, Shawn A., Perlin, David S., Pfaller, Michael A.
Published 2013

Stress-Induced Changes in the Lipid Microenvironment of β-(1,3)-d-Glucan Synthase Cause Clinically Important Echinocandin Resistance in Aspergillus fumigatus

by Satish, Shruthi, Jiménez-Ortigosa, Cristina, Zhao, Yanan, Lee, Min Hee, Dolgov, Enriko, Krüger, Thomas, Park, Steven, Denning, David W., Kniemeyer, Olaf, Brakhage, Axel A., Perlin, David S.
Published in mBio (2019)