Enfumafungin Derivative MK-3118 Shows Increased In Vitro Potency against Clinical Echinocandin-Resistant Candida Species and Aspergillus Species Isolates

Por Jiménez-Ortigosa, Cristina, Paderu, Padmaja, Motyl, Mary R., Perlin, David S.
Publicado em 2014

Genetic Drivers of Multidrug Resistance in Candida glabrata

Por Healey, Kelley R., Jimenez Ortigosa, Cristina, Shor, Erika, Perlin, David S.
Publicado no Front Microbiol (2016)

Emergence of Echinocandin Resistance Due to a Point Mutation in the fks1 Gene of Aspergillus fumigatus in a Patient with Chronic Pulmonary Aspergillosis

Por Jiménez-Ortigosa, Cristina, Moore, Caroline, Denning, David W., Perlin, David S.
Publicado no Antimicrob Agents Chemother (2017)

De Novo Acquisition of Resistance to SCY-078 in Candida glabrata Involves FKS Mutations That both Overlap and Are Distinct from Those Conferring Echinocandin Resistance

Por Jiménez-Ortigosa, Cristina, Perez, Winder B., Angulo, David, Borroto-Esoda, Katyna, Perlin, David S.
Publicado no Antimicrob Agents Chemother (2017)

Quick Detection of FKS1 Mutations Responsible for Clinical Echinocandin Resistance in Candida albicans

Por Dudiuk, Catiana, Gamarra, Soledad, Jimenez-Ortigosa, Cristina, Leonardelli, Florencia, Macedo, Daiana, Perlin, David S., Garcia-Effron, Guillermo
Publicado no J Clin Microbiol (2015)

Target Enzyme Mutations Confer Differential Echinocandin Susceptibilities in Candida kefyr

Por Staab, Janet F., Neofytos, Dionysios, Rhee, Peter, Jiménez-Ortigosa, Cristina, Zhang, Sean X., Perlin, David S., Marr, Kieren A.
Publicado em 2014

Set of Classical PCRs for Detection of Mutations in Candida glabrata FKS Genes Linked with Echinocandin Resistance

Por Dudiuk, Catiana, Gamarra, Soledad, Leonardeli, Florencia, Jimenez-Ortigosa, Cristina, Vitale, Roxana G., Afeltra, Javier, Perlin, David S., Garcia-Effron, Guillermo
Publicado em 2014

CD101: a novel long‐acting echinocandin

Por Zhao, Yanan, Perez, Winder B., Jiménez‐Ortigosa, Cristina, Hough, Grayson, Locke, Jeffrey B., Ong, Voon, Bartizal, Ken, Perlin, David S.
Publicado no Cell Microbiol (2016)

Tolerance to Caspofungin in Candida albicans Is Associated with at Least Three Distinctive Mechanisms That Govern Expression of FKS Genes and Cell Wall Remodeling

Por Yang, Feng, Zhang, Lulu, Wakabayashi, Hironao, Myers, Jason, Jiang, Yuanying, Cao, Yongbing, Jimenez-Ortigosa, Cristina, Perlin, David S., Rustchenko, Elena
Publicado no Antimicrob Agents Chemother (2017)

Correction for Yang et al., “Tolerance to Caspofungin in Candida albicans Is Associated with at Least Three Distinctive Mechanisms That Govern Expression of FKS Genes and Cell Wall...

Por Yang, Feng, Zhang, Lulu, Wakabayashi, Hironao, Myers, Jason, Jiang, Yuanying, Cao, Yongbing, Jimenez-Ortigosa, Cristina, Perlin, David S., Rustchenko, Elena
Publicado no Antimicrob Agents Chemother (2018)

Breakthrough Candidemia Due to Multidrug-Resistant Candida glabrata during Prophylaxis with a Low Dose of Micafungin

Por Bizerra, Fernando César, Jimenez-Ortigosa, Cristina, Souza, Ana Carolina R., Breda, Giovanni Luis, Queiroz-Telles, Flávio, Perlin, David S., Colombo, Arnaldo L.
Publicado em 2014

Echinocandin-resistant Candida tropicalis Bloodstream Infections

Por Sfeir, Maroun, Jiménez-Ortigosa, Cristina, Schuetz, Audrey, Jenkins, Stephen, Jones, Sian, Soave, Rosemary, Van Besien, Koen, Satlin, Michael, Small, Catherine, Perlin, David, Walsh, Thomas
Publicado no Open Forum Infect Dis (2017)

Increasing Echinocandin Resistance in Candida glabrata: Clinical Failure Correlates With Presence of FKS Mutations and Elevated Minimum Inhibitory Concentrations

Por Alexander, Barbara D., Johnson, Melissa D., Pfeiffer, Christopher D., Jiménez-Ortigosa, Cristina, Catania, Jelena, Booker, Rachel, Castanheira, Mariana, Messer, Shawn A., Perlin, David S., Pfaller, Michael A.
Publicado em 2013

Chitin Synthases with a Myosin Motor-Like Domain Control the Resistance of Aspergillus fumigatus to Echinocandins

Por Jiménez-Ortigosa, Cristina, Aimanianda, Vishukumar, Muszkieta, Laetitia, Mouyna, Isabelle, Alsteens, David, Pire, Stéphane, Beau, Remi, Krappmann, Sven, Beauvais, Anne, Dufrêne, Yves F., Roncero, César, Latgé, Jean-Paul
Publicado em 2012

Prevalent mutator genotype identified in fungal pathogen Candida glabrata promotes multi-drug resistance

Por Healey, Kelley R., Zhao, Yanan, Perez, Winder B., Lockhart, Shawn R., Sobel, Jack D., Farmakiotis, Dimitrios, Kontoyiannis, Dimitrios P., Sanglard, Dominique, Taj-Aldeen, Saad J., Alexander, Barbara D., Jimenez-Ortigosa, Cristina, Shor, Erika, Perlin, David S.
Publicado no Nat Commun (2016)

Changes in In Vitro Susceptibility Patterns of Aspergillus to Triazoles and Correlation With Aspergillosis Outcome in a Tertiary Care Cancer Center, 1999–2015

Por Heo, Sang Taek, Tatara, Alexander M., Jiménez-Ortigosa, Cristina, Jiang, Ying, Lewis, Russell E., Tarrand, Jeffrey, Tverdek, Frank, Albert, Nathaniel D., Verweij, Paul E., Meis, Jacques F., Mikos, Antonios G., Perlin, David S., Kontoyiannis, Dimitrios P.
Publicado no Clin Infect Dis (2017)