De Novo Acquisition of Resistance to SCY-078 in Candida glabrata Involves FKS Mutations That both Overlap and Are Distinct from Those Conferring Echinocandin Resistance

SCY-078 is an orally active antifungal whose target is the β-(1,3)-d-glucan synthase (GS). We evaluated the spontaneous emergence of SCY-078-resistant Candida glabrata isolates following drug exposure in vitro. Resistant isolates were analyzed using broth microdilution methodology and FKS sequencing...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Jiménez-Ortigosa, Cristina, Perez, Winder B., Angulo, David, Borroto-Esoda, Katyna, Perlin, David S.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2017
Témata:
Mechanisms of Resistance
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5571364/
https://ncbi.nlm.nih.gov/pubmed/28630180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00833-17
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