Limited ERG11 Mutations Identified in Isolates of Candida auris Directly Contribute to Reduced Azole Susceptibility

Multiple Erg11 amino acid substitutions were identified in clinical isolates of Candida auris originating from India and Colombia. Elevated azole MICs were detected in Saccharomyces cerevisiae upon heterologous expression of C. auris ERG11 alleles that encoded for Y132F or K143R substitutions; howev...

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Publicat a:Antimicrob Agents Chemother
Autors principals: Healey, Kelley R., Kordalewska, Milena, Jiménez Ortigosa, Cristina, Singh, Ashutosh, Berrío, Indira, Chowdhary, Anuradha, Perlin, David S.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2018
Matèries:
Mechanisms of Resistance
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6153782/
https://ncbi.nlm.nih.gov/pubmed/30082281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01427-18
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