Method to Screen Substrates of Apical Sodium-Dependent Bile Acid Transporter

Human apical sodium-dependent bile acid transporter (hASBT) is a potential prodrug target under study. Development of prodrugs that target hASBT may yield compounds with low solubility and/or susceptibility to hydrolysis. A transport uptake method is needed that increases compound solubility and avo...

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Bibliographic Details
Main Authors: Rais, Rana, Gonzalez, Pablo M., Zheng, Xiaowan, Wring, Stephen A., Polli, James E.
Format: Artigo
Language:Inglês
Published: Springer US 2008
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2628203/
https://ncbi.nlm.nih.gov/pubmed/19085111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-008-9069-9
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