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Molecular Switch Controlling the Binding of Anionic Bile Acid Conjugates to Human Apical Sodium-dependent Bile Acid Transporter

The human apical sodium-dependent bile acid transporter (hASBT) may serve as a prodrug target for oral drug absorption. Synthetic, biological, NMR and computational approaches identified the structure-activity relationships of mono- and dianionic bile acid conjugates for hASBT binding. Experimental...

詳細記述

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書誌詳細
主要な著者: Rais, Rana, Acharya, Chayan, Tririya, Gasirat, MacKerell, Alexander D., Polli, James E.
フォーマット: Artigo
言語:Inglês
出版事項: 2010
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2891776/
https://ncbi.nlm.nih.gov/pubmed/20504026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm1003683
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