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Computational Models for Drug Inhibition of the Human Apical Sodium-dependent Bile Acid Transporter
The human apical sodium-dependent bile acid transporter (ASBT; SLC10A2) is the primary mechanism for intestinal bile acid re-absorption. In the colon, secondary bile acids increase the risk of cancer. Therefore, drugs that inhibit ASBT have the potential to increase the risk of colon cancer. The obj...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2757534/ https://ncbi.nlm.nih.gov/pubmed/19673539 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp900163d |
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