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Inhibition Requirements of the human Apical Sodium-dependent Bile acid Transporter (hASBT) using Aminopiperidine Conjugates of glutamyl-Bile Acids

PURPOSE: Synthesize aminopiperidine conjugates of glutamyl-bile acids (glu-BAs) and develop a hASBT inhibition model using the conformationally sampled pharmacophore (CSP) approach. METHODS: glu-BAs aminopiperidine conjugates were synthesized. hASBT inhibition was measured as K(i). A CSP-SAR model w...

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Detalhes bibliográficos
Main Authors: González, Pablo M., Acharya, Chayan, MacKerell, Alexander D., Polli, James E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2882941/
https://ncbi.nlm.nih.gov/pubmed/19384469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-009-9877-3
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