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Structural Determinants for Transport Across the Intestinal Bile Acid Transporter Using C-24 Bile Acid Conjugates

The human apical sodium dependent bile acid transporter (hASBT) re-absorbs gram quantities of bile acid daily and is a potential prodrug target to increase oral drug absorption. In the absence of a high resolution hASBT crystal structure, 3D-QSAR modeling may prove beneficial in designing prodrug ta...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Rais, Rana, Acharya, Chayan, MacKerell, Alexander D., Polli, James E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2997912/
https://ncbi.nlm.nih.gov/pubmed/20939504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp100233v
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