Chemotherapy of Human African Trypanosomiasis

Por Bacchi, Cyrus J.
Publicado em 2009

Multiple Triclosan Targets in Trypanosoma brucei

Por Paul, Kimberly S., Bacchi, Cyrus J., Englund, Paul T.
Publicado em 2004

Effects of Some Antitumor Agents on Growth and Glycolytic Enzymes of the Flagellate Crithidia

Por Bacchi, Cyrus J., Ciaccio, Edward I., Koren, Lois E.
Publicado em 1969

Antitrypanosomal Activity of a New Triazine Derivative, SIPI 1029, In Vitro and in Model Infections

Por Bacchi, Cyrus J., Vargas, Marcus, Rattendi, Donna, Goldberg, Burt, Zhou, Weicheng
Publicado em 1998

Identification and characterization of a novel flavin-containing spermine oxidase of mammalian cell origin.

Por Vujcic, Slavoljub, Diegelman, Paula, Bacchi, Cyrus J, Kramer, Debora L, Porter, Carl W
Publicado em 2002

Novel Trypanocidal Analogs of 5′-(Methylthio)-Adenosine

Por Sufrin, Janice R., Spiess, Arthur J., Marasco, Canio J., Rattendi, Donna, Bacchi, Cyrus J.
Publicado em 2008

Metabolism of an Alkyl Polyamine Analog by a Polyamine Oxidase from the Microsporidian Encephalitozoon cuniculi

Por Bacchi, Cyrus J., Yarlett, Nigel, Faciane, Evangeline, Bi, Xiangdong, Rattendi, Donna, Weiss, Louis M., Woster, Patrick M.
Publicado em 2009

Trypanocidal Activity of 8-Methyl-5′-{[(Z)-4-Aminobut-2-enyl]-(Methylamino)}Adenosine (Genz-644131), an Adenosylmethionine Decarboxylase Inhibitor

Por Bacchi, Cyrus J., Barker, Robert H., Rodriguez, Aixa, Hirth, Bradford, Rattendi, Donna, Yarlett, Nigel, Hendrick, Clifford L., Sybertz, Edmund
Publicado em 2009

2,4-Diaminopyrimidines as Potent Inhibitors of Trypanosoma brucei and Identification of Molecular Targets by a Chemical Proteomics Approach

Por Mercer, Luke, Bowling, Tana, Perales, Joe, Freeman, Jennifer, Nguyen, Tien, Bacchi, Cyrus, Yarlett, Nigel, Don, Robert, Jacobs, Robert, Nare, Bakela
Publicado em 2011

Alkanediamide-Linked Bisbenzamidines Are Promising Antiparasitic Agents

Por Vanden Eynde, Jean J., Mayence, Annie, Mottamal, Madhusoodanan, Bacchi, Cyrus J., Yarlett, Nigel, Kaiser, Marcel, Brun, Reto, Huang, Tien L.
Publicado no Pharmaceuticals (Basel) (2016)

Novel Alkylpolyamine Analogues That Possess Both Antitrypanosomal and Antimicrosporidial Activity

Por Zou, Yu, Wu, Zhiqian, Sirisoma, Nilantha, Woster, Patrick M., Casero, Robert A., Weiss, Louis M., Rattendi, Donna, Lane, Schennella, Bacchi, Cyrus J.
Publicado em 2001

Polyamine metabolism in a member of the phylum Microspora (Encephalitozoon cuniculi): effects of polyamine analogues

Por Bacchi, Cyrus J., Rattendi, Donna, Faciane, Evangeline, Yarlett, Nigel, Weiss, Louis M., Frydman, Benjamin, Woster, Patrick, Wei, Benjamin, Marton, Laurence J., Wittner, Murray
Publicado em 2004

Synthesis and SAR of alkanediamide-linked bisbenzamidines with anti-trypanosomal and anti-pneumocystis activity

Por Huang, Tien L., Eynde, Jean Jacques Vanden, Mayence, Annie, Collins, Margaret S., Cushion, Melanie T., Rattendi, Donna, Londono, Indira, Mazumder, Lakshman, Bacchi, Cyrus J., Yarlett, Nigel
Publicado em 2009

Novel Synthetic Polyamines Are Effective in the Treatment of Experimental Microsporidiosis, an Opportunistic AIDS-Associated Infection

Por Bacchi, Cyrus J., Weiss, Louis M., Lane, Schenella, Frydman, Benjamin, Valasinas, Aldonia, Reddy, Venodhar, Sun, Jerry S., Marton, Laurence J., Khan, Imitiaz A., Moretto, Magali, Yarlett, Nigel, Wittner, Murray
Publicado em 2002

Pharmacokinetics and pharmacodynamics utilizing unbound target tissue exposure as part of a disposition-based rationale for lead optimization of benzoxaboroles in the treatment of...

Por WRING, STEPHEN, GAUKEL, ERIC, NARE, BAKELA, JACOBS, ROBERT, BEAUDET, BETH, BOWLING, TANA, MERCER, LUKE, BACCHI, CYRUS, YARLETT, NIGEL, RANDOLPH, RYAN, PARHAM, ROBIN, REWERTS, CINDY, PLATNER, JACOB, DON, ROBERT
Publicado em 2014

Assessment of a pretomanid analogue library for African trypanosomiasis: Hit-to-lead studies on 6-substituted 2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazine 8-oxides

Por Thompson, Andrew M., Marshall, Andrew J., Maes, Louis, Yarlett, Nigel, Bacchi, Cyrus J., Gaukel, Eric, Wring, Stephen A., Launay, Delphine, Braillard, Stephanie, Chatelain, Eric, Mowbray, Charles E., Denny, William A.
Publicado no Bioorg Med Chem Lett (2018)

Novel S-Adenosylmethionine Decarboxylase Inhibitors for the Treatment of Human African Trypanosomiasis

Por Barker, Robert H., Liu, Hanlan, Hirth, Bradford, Celatka, Cassandra A., Fitzpatrick, Richard, Xiang, Yibin, Willert, Erin K., Phillips, Margaret A., Kaiser, Marcel, Bacchi, Cyrus J., Rodriguez, Aixa, Yarlett, Nigel, Klinger, Jeffrey D., Sybertz, Edmund
Publicado em 2009

Discovery of Novel Benzoxaborole-Based Potent Antitrypanosomal Agents

Por Ding, Dazhong, Zhao, Yaxue, Meng, Qingqing, Xie, Dongsheng, Nare, Bakela, Chen, Daitao, Bacchi, Cyrus J., Yarlett, Nigel, Zhang, Yong-Kang, Hernandez, Vincent, Xia, Yi, Freund, Yvonne, Abdulla, Maha, Ang, Kean-Hooi, Ratnam, Joseline, McKerrow, James H., Jacobs, Robert T., Zhou, Huchen, Plattner, Jacob J.
Publicado em 2010

Discovery of Novel Orally Bioavailable Oxaborole 6-Carboxamides That Demonstrate Cure in a Murine Model of Late-Stage Central Nervous System African Trypanosomiasis

Por Nare, Bakela, Wring, Stephen, Bacchi, Cyrus, Beaudet, Beth, Bowling, Tana, Brun, Reto, Chen, Daitao, Ding, Charles, Freund, Yvonne, Gaukel, Eric, Hussain, Ali, Jarnagin, Kurt, Jenks, Matthew, Kaiser, Marcel, Mercer, Luke, Mejia, Elena, Noe, Andy, Orr, Matt, Parham, Robin, Plattner, Jacob, Randolph, Ryan, Rattendi, Donna, Rewerts, Cindy, Sligar, Jessica, Yarlett, Nigel, Don, Robert, Jacobs, Robert
Publicado em 2010

SCYX-7158, an Orally-Active Benzoxaborole for the Treatment of Stage 2 Human African Trypanosomiasis

Por Jacobs, Robert T., Nare, Bakela, Wring, Stephen A., Orr, Matthew D., Chen, Daitao, Sligar, Jessica M., Jenks, Matthew X., Noe, Robert A., Bowling, Tana S., Mercer, Luke T., Rewerts, Cindy, Gaukel, Eric, Owens, Jennifer, Parham, Robin, Randolph, Ryan, Beaudet, Beth, Bacchi, Cyrus J., Yarlett, Nigel, Plattner, Jacob J., Freund, Yvonne, Ding, Charles, Akama, Tsutomu, Zhang, Y.-K., Brun, Reto, Kaiser, Marcel, Scandale, Ivan, Don, Robert
Publicado em 2011