2,4-Diaminopyrimidines as Potent Inhibitors of Trypanosoma brucei and Identification of Molecular Targets by a Chemical Proteomics Approach

BACKGROUND: There is an urgent need to develop new, safe and effective treatments for human African trypanosomiasis (HAT) because current drugs have extremely poor safety profiles and are difficult to administer. Here we report the discovery of 2,4-diaminopyrimidines, exemplified by 4-[4-amino-5-(2-...

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Detalhes bibliográficos
Main Authors: Mercer, Luke, Bowling, Tana, Perales, Joe, Freeman, Jennifer, Nguyen, Tien, Bacchi, Cyrus, Yarlett, Nigel, Don, Robert, Jacobs, Robert, Nare, Bakela
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3035674/
https://ncbi.nlm.nih.gov/pubmed/21347454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0000956
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