Cure of murine Trypanosoma brucei rhodesiense infections with an S-adenosylmethionine decarboxylase inhibitor.

The compound 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine (MDL73811), a potent inhibitor of S-adenosylmethionine decarboxylase, was effective in mice against six of eight clinical isolates of Trypanosoma brucei rhodesiense, the causative agent of East African sleeping sickness...

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Main Authors: Bacchi, C J, Nathan, H C, Yarlett, N, Goldberg, B, McCann, P P, Bitonti, A J, Sjoerdsma, A
格式: Artigo
語言:Inglês
出版: 1992
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC245537/
https://ncbi.nlm.nih.gov/pubmed/1482141
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