Cure of murine Trypanosoma brucei rhodesiense infections with an S-adenosylmethionine decarboxylase inhibitor.

The compound 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine (MDL73811), a potent inhibitor of S-adenosylmethionine decarboxylase, was effective in mice against six of eight clinical isolates of Trypanosoma brucei rhodesiense, the causative agent of East African sleeping sickness. In combi...

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Publicado en:	Antimicrob Agents Chemother
Autores principales:	Bacchi, C J, Nathan, H C, Yarlett, N, Goldberg, B, McCann, P P, Bitonti, A J, Sjoerdsma, A
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Microbiology (ASM) 1992
Materias:	Research Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC245537/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1482141/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.36.12.2736
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